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KMID : 0895820100200040017
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Journal of Oriental Rehabilitation Medicine
2010 Volume.20 No. 4 p.17 ~ p.31
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Effects of Yeast Fermented Ganoderma Lucidum Extract on the Recovery of Exercise Fatigue in Forced Swimming Rats
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Park Ji-Hun
Kim Ho-Jun
Lee Myeong-Jong
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Abstract
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Objectives :Ganoderma Lucidum has been used in traditional oriental medicine to treat various conditions including chronic fatigue and cough. This experimental study was designed to investigate the effects of yeast-fermented Ganoderma Lucidum extract on the fatigue of rats elicited by forced swimming.
Materials and methods :The rat subjects were divided into 4 groups: normal group, control group administered with 0.9% normal saline, experimental Ⅰ(Exp Ⅰ) group administered with yeast-fermented Ganoderma lucidum extract and experimental Ⅱ(Exp Ⅱ) group administered with Ganoderma Lucidum extract for 4 weeks. All the serum samples collected by heart puncture were used to measure biochemical factors such as glucose, lactate, lactate dehydrogenase(LDH), creatine kinase(CK), inorganic phosphorus, ammonia, total cholesterol(TC), triglycerides(TG), high-density lipoprotein(HDL), low-density lipoprotein(LDL), aspartate transaminase(AST), alanine transaminase(ALT).
Results :1. Weight change and swimming time were not significantly different in the experimental groups as compared with control group. 2. Lactate was significantly decreased in the experimental groups as compared with control group. Inorganic phosphorus was also significantly decreased in the Exp Ⅰ group as compared with control group(p<0.05). 3. Serum lipid concentration was not significantly different in the experimental groups as compared with control group. 4. AST and ALT were significantly decrease in the experimental groups as compared with control group.
Conclusions :Yeast-fermented Ganoderma lucidum in forced swimming rats would appear to reduce fatigue-related factors, AST, ALT of serum and promote anti-fatigue effect.
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KEYWORD
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Ganoderma lucidum, Yeast fermentation, Forced swimming, Anti-fatigue
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